Isitofu se-Adipotide 2mg

I-Adipotide (i-aka FTPP okanye i-proapototic peptide) ibulala iiseli ezinamafutha, ngokucacileyo kwaye zilula, ngokujolisa ukunikezelwa kwegazi kwezo seli.Okubangela umdla kukuba, i-adipotide iyakwazi ukubona imithambo yegazi kwiiseli ezinamafutha ukusuka kwimithambo yegazi kuwo wonke umzimba kwaye ke ngoko ikhetha kakhulu.Uphando kwiinkawu lubonisa ukuba i-adipotide ayibangeli ukwehla kobunzima kuphela, inyusa ubuntununtunu be-insulin kwaye isusa ezinye zeziphumo zohlobo lwe-2 yeswekile.

USetyenziso lweMveliso: Lo MVELISO KUJWENZISWA NJENGEMKHEMIKHALI YOPHANDO KUPHELA.Olu bizo luvumela ukusetyenziswa kweekhemikhali zophando ngokungqongqo kuvavanyo lwe-in vitro kunye novavanyo lwaselabhoratri kuphela.Lonke ulwazi lwemveliso olukhoyo kule webhusayithi lulungiselelwe iinjongo zemfundo kuphela.Ukungenisa emzimbeni walo naluphi na uhlobo ebantwini okanye kwizilwanyana kwalelwe ngokungqongqo ngumthetho.Le mveliso kufuneka iphathwe kuphela ngabasebenzi abanelayisensi, abaqeqeshiweyo.Le mveliso ayilochiza, ukutya, okanye izithambiso kwaye ayinakubizwa kakubi, isetyenziswe kakubi okanye idunyiswe njengechiza, ukutya okanye izithambiso.

Ulandelelwano: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys—Gly-Gly–(Lys-Leu-Ala-Lys-Leu-Ala-Lys)2
Ifomula yeemolekyuli: C152H252N44O42
Ubunzima beMolekyuli: 2611.41 g / mol

I-Adipotide yaphuhliswa kwaye yafakwa kwisigaba I solingo lwezonyango kwi-2011 ukuphanda amandla ayo okubulala iiseli ezinamafutha.Uvavanyo kwiinkawu ze-rhesus lubonise ukuba i-adipotide ibangela i-apoptosis ekujoliswe kuyo kwimithambo yegazi ye-white adipose tissue (amafutha).Ngaphandle konikezelo lwegazi, iiseli ezinamafutha zavele zafa.Isiphumo somnatha sasikukulahleka kwesisindo esikhawulezileyo, ukuncipha ngokukhawuleza kwisalathiso sobunzima bomzimba (BMI), kunye nokuphuculwa kweempawu zokumelana ne-insulin.Okubangel 'umdla kukuba, unyango nge-adipotide kunye nokulahlekelwa ngamafutha emva koko akuphuculanga kuphela ubunzima, kodwa ngokwenene kube negalelo ekutshintsheni indlela yokutya.Iinkawu eziye zaphulukana nobunzima nge-adipotide nazo zabonisa ukuncipha kokusetyenziswa kokutya[1].

A. Ipesenti yokulahlekelwa kwesisindo kumaqela olawulo (oluhlaza okwesibhakabhaka) ngokuchasene nalabo baphathwa nge-adipotide (iidosi ezimbini ezihlukeneyo, eziboniswe ngobomvu)
B. Ipesenti yokunciphisa i-BMI (ulawulo oluchasene nonyango)

A. Ibonisa utshintsho kwiimfuno ze-insulin (ummandla ophantsi kwegophe) ukuze uphathwe (obomvu) kunye namaqela olawulo (oluhlaza okwesibhakabhaka).I-AUC yabalwa kuvavanyo lwe-IVGTT.
B. Ibonisa isalathisi se-insulinogenic ngaphambi nangemva konyango (obomvu) kunye nokulawula (blue) amaqela.Amaqela anyangwayo abonisa ukwehla okukhulu kwi-insulin secretion.
C. Utshintsho ekusebenziseni ibhisikidi kumaqela aphathwayo (obomvu) kunye nolawulo (oluhlaza okwesibhakabhaka).

Ukujoliswa kwe-adipotide kwimithambo yegazi ekhonza iiseli ezinamafutha kunokungenelela kwiprotein receptor ebizwa ngokuba yi-prohibitin.I-Prohibitin yiprotheni ye-membrane enokuthi ifumaneke kuphela kwimithambo yegazi ekhonza amanqatha amhlophe kunye neeseli zomhlaza.Kuye kwaboniswa ukuba i-adipotide inxulumana nale proteni[2].Ukuba kuvela ukuba i-prohibitin ifumaneka kuphela kwi-fat vasculature kunye nezicubu zomhlaza, ngoko uvavanyo lwe-adipotide luya kuba noxanduva lokuchonga i-fat-specific target engasetyenziselwa iinjongo zonyango kuphela, kodwa ngeenjongo zokuxilonga ngokunjalo.