SR9009 iipilisi 100 tablets/ibhotile

Igama lemveliso:SR9009

I-Spacification: 10 mg / ipilisi 100 iipilisi / ibhotile

Ixabiso:$80/ibhotile

MOQ: 1 ibhotile

ILab: uLianFu Bio

Ukuchazwa kwemveliso

I-SR9009, i-REV-ERBiagonist, kwandisa ukunyanzeliswa kwe-genesis elawulwa yi-REV-ERBα / ERBβ (IC50: 670/800 nM).Ngokusebenzisa i-REV-ERB, i-SR9009 inokunciphisa umsebenzi we-circadian locomotor ngexesha lesigaba sobumnyama kwaye iguqule ipateni yokubonakalisa i-core clock genes kwi-hypothalami yeempuku.Ipateni ye-circadian yokubonakalisa uluhlu lwemizila ye-metabolic esibindini, isihlunu samathambo, kunye nezicubu ze-adipose nazo zatshintshwa kwiimpuku ezivezwe kwi-SR9009, okukhokelela ekonyukeni kwenkcitho yamandla.

I-SR9009 (100 mg / kg, ip, ibhidi, iintsuku ezingama-30) inakhoukunciphisa ubunzima bamafuthakwaye ngokumangalisayoukuphucula i-dyslipidemiakwayei-hyperglycemia.