Umgubo wezonyango MK-677
Ingcaciso yeMveliso
| Inombolo yeCAS | 159752-10-0 |
| Imbonakalo | umgubo |
| Amagama emichiza | Ibutamoren;I-CHEMBL13817;S1151_Thengisa;UNII-GJ0EGN38UL;159634-47-6;MK-0677; |
| Ifomula yeemolekyuli | I-C27H36N4O5S |
| Ubunzima beMolekyuli | 528.66354 g/mol |
MK-677
I-MK-677, eyaziwa nangokuthi i-Ibutamoren, i-SARM yomlomo engekho-steroidal (i-modulator ye-androgen receptor ekhethiweyo) esetyenziswa ngokuqhelekileyo ngenjongo yokwandisa amanqanaba e-hormone yokukhula emzimbeni.Isithako esisebenzayo kwi-MK-677 yikhemikhali eyaziwa ngokuba yi-Ibutamoren Mesylate.
I-Ibutamoren Mesylate isebenza ngokuvula i-ghrelin receptor, ejongene nokukhuthaza ukuveliswa kwehomoni yokukhula.I-agonist ekhethiweyo kakhulu, oku kuthetha ukuba ijolise ngokukodwa kwaye isebenze i-ghrelin receptor, ekhokelela ekukhuleni kwehomoni yokukhula.
Uphononongo lubonise ukuba i-MK-677 inokunyusa ngokufanelekileyo amanqanaba e-hormone yokukhula ngokuphindwe kabini, okukhokelela ekuphuculeni ubunzima bemisipha, ukunciphisa amanqatha omzimba, ukuxinana kwamathambo, kunye nokuphucula umgangatho wokulala.Kwakhona kucingelwa ukuba kuneempawu zokuchasana nokuguga, njengoko amanqanaba e-hormone yokukhula aphakanyisiweyo adityaniswa nokunciphisa izinga lokuguga kunye nokwandisa ixesha elide.
Ukunyusa izinga lehomoni yokukhula.I-hormone yokukhula yomlomo engekho-peptide ivuselela ukukhululwa kwe-GH ngokusebenzisa i-receptors kwi-pituitary gland kunye ne-hypothalamus, eyahluke kwi-hormone yokukhula ekhupha i-hormone receptors.I-MK-677 yi-hormone yokukhula esebenzayo yomlomo, elinganisa umphumo we-GH ekukhuthazeni amahomoni angapheliyo.Kuye kwaboniswa ukwandisa ukukhululwa kunye nokuvelisa ukukhula okuqhubekayo kwamahomoni e-plasma, kuquka i-hormone yokukhula kunye ne-IGF-1, kodwa ayichaphazeli amanqanaba eCortisol.
Njengalo naliphi na iyeza elitsha okanye isongezelelo, kubalulekile ukubonisana nochwepheshe bezempilo abaqeqeshiweyo ngaphambi kokusebenzisa iMK-677.
Ukuqukumbela, i-MK-677 sisongezelelo esisebenzayo sokunyusa amanqanaba e-hormone yokukhula kunye nokukhuthaza impilo kunye nokuphila kakuhle.Nangona kunjalo, uphando oluninzi luyafuneka ukuze kuqinisekiswe ukhuseleko lwalo lwexesha elide kunye nokusebenza kakuhle, kunye nokuqonda ngokupheleleyo impembelelo yalo kumzimba womntu.Njengesiqhelo, kubalulekile ukuqhubeka ngononophelo xa usebenzisa nasiphi na isongezelelo esitsha kunye nokubonisana nochwepheshe bezempilo ngaphambi kokuba uqale irejimeni entsha.
