Yeyona coenzyme encinci yomlingo egcina imizimba yethu inkenteza.Nantsi indlela esebenza ngayo i-NAD + kwaye kutheni abantu abaninzi beyibona njengendlela yokulwa nokuguga.
Njengoko imarike yokunqanda ukwaluphala iye yakhula kwiminyaka yakutshanje, izazinzulu bezikhangela naziphi na iikhompawundi ezinokucothisa okanye zibuyisele umva iziphumo zokwaluphala.Rhoqo izisombululo zabo zilala ekufumaneni izinto eziguqukayo njengoko sikhula, kwaye enye yezona zinto zibalulekileyo kwezi ibe yiNAD +.Oku kubonakaliswe kwinani elikhulayo lezongezo ezichasene nokwaluphala ezifuna ukuphucula ubomi obude - kodwa wakuba ukhuhla ngaphantsi kwe-hype ngaba kukho into enokonwaba ngayo?Nantsi into eyiNAD +, isebenza njani kwaye kutheni ibaluleke kangaka emzimbeni wakho nakwimpilo yakho.
Yintoni i-NAD+?
Njengoko sikhula, umzimba wethu ulahlekelwa zizinto ezithile kunye neemolekyuli ezinokubaluleka ekusigcineni siselula.Enye yezi yi-nicotinamide adenine dinucleotide, eyaziwa ngcono njenge-NAD+.
Oosonzululwazi baqala bajonga ubukho beNAD+ emva phaya ngo-1906. Ukusukela ngoko, ukuqonda kwethu ngayo kuye kwanda ngokuthe ngcembe.Ifunyenwe inzima emsebenzini kwiiseli zabantu, izilwanyana, izityalo kunye negwele ligcina yonke into ihamba kakuhle.
I-NAD+ yi-coenzyme ebalulekileyo enokufumaneka kwiseli nganye emzimbeni wakho.Isebenza imisebenzi emibini ephambili - ukuguqula izondlo zibe amandla kwaye ngumdlali obalulekileyo kwinkqubo ye-metabolic, ekhonza njengomncedisi omncinci onobungane ekulawuleni eminye imisebenzi yeselula.
Isebenza ngokufanelekileyo njengomthuthi omncinci ohambisa ii-electron ukusuka kwi-molecule ukuya kwenye ukwenza zonke iintlobo zokuphendula kunye neenkqubo.Ecaleni kwenye imolekyuli, i-NADH, ithatha inxaxheba kwinani leempendulo ezivelisa amandla ngaphakathi kweeseli zethu.Ikwanceda ukulawula isigqi sethu se-circadian esilawula ukulala / ukuvuka kwethu.
Yaqala ukufunyanwa ngo-1906 nguUnzima kunye noNcincinjengenxalenye yokunyusa izinga lokubiliswa kotywala kwiincindi zegwele.Ukususela ngoko, ukuqonda kwethu kuye kwanda kakhulu, yaye kuye kwasetyenziswa ukulwa nezifo ezininzi.
Kutheni i-NAD + ibalulekile
I-NAD+ sisixhobo, okanye isibaso, kwezinye iimolekyuli ezinceda umzimba ukuba wenze okona kulungileyo.Xa amanqanaba ehla, imisebenzi nayiphi na i-NAD (H) exhomekeke kwi-enzymes kwi-phosphorylation ye-oxidative, umjikelezo we-TCA, kunye ne-glycolysis iyathintelwa.
Oku kubangela imveliso ephantsi ye-ATP.Inokuchaphazela amanqanaba e-PARP kunye ne-sirtuins kwaye ikhokelela ekungasebenzini kweendlela ezithile ze-molecular ezisezantsi ezidlala indima ekulungiseni i-DNA.
Ngamanye amazwi, ngaphandle kwawo umzimba wethu awusebenzi kakuhle njengoko ubunokwenza, awusebenzi kangako ekuzilungiseni kwaye ukhokelela kwisantya esicothayo semetabolism.Ngaphandle kokuba i-NAD + isebenze njengeteksi encinci ebalulekileyo, iiseli zakho ziya kuvelisa amandla amancinci afunwa ngumzimba ukuze uphile kwaye wenze imisebenzi yawo.
Ukubaluleka kwe-NAD +, ke ngoko, akusuki kuyo nayiphi na isithako somlingo, kodwa amandla ayo okunceda ezinye iimolekyuli eziluncedo zenze imisebenzi yazo.Ukuba besijonga umzimba njengeqela lebhola ekhatywayo, i-NAD + izakuba ngumdlali wasesiswini osembindini, isenza izinto kwaye ibonelele ngolawulo olunceda abahlaseli babeke ibhola emnatheni.
Ayinabukhazikhazi, ayibonakali kodwa ngaphandle kwayo, wonke umsebenzi uyawa.Ezo molekyuli zibalulekileyo ekulungiseni iiseli, ukuphucula imetabolism yethu kunye nokulawula imisebenzi yebhayoloji.Ngaphandle kwayo sinokuba namava ainani leengxaki zempilo.
Iinzuzo zengqondo zonyango lwe-NAD +
Enye yeempawu zokuguga kukulahlekelwa ngumsebenzi wokuqonda.Uthanda ukulibala izinto, ube nengxaki yokugxila, kwaye uzive ngathi ingqondo yakho inamafu okanye inkungu.Unyango lwe-NAD luthatha indawo ye-coenzyme efunekayo ukucotha okanye ukumisa ukuqhubela phambili koku kuncipha.Uya kuba:
- Ukwanda kokucaca kwengqondo
- Inkumbulo engcono
- Ukugxininiswa okuphezulu
- Iimoods eziphuculweyo
- Izakhono ezingcono zokusombulula iingxaki
Ukomelela ekusebenzeni kwengqondo okufumana kunyango lwe-NAD kunokukunceda ukuba ulwe nobunzima obungapheliyo bengqondo njengoxinzelelo, ixhala, kunye nolunye ukuphazamiseka kweemvakalelo.
Izibonelelo zomzimba zonyango lwe-NAD +
I-NAD ngamanye amaxesha ibizwa ngokuba "yi-molecule yomncedisi" kuba idibanisa nezinye ii-enzymes kwaye ibancede benze umsebenzi wabo ngcono.Okwenzeka kwiiseli zakho kwenza umahluko omkhulu kwindlela okhangeleka ngayo noziva ngayo.Uluhlu lweenzuzo zomzimba ezivela kunyango lwe-NAD lude, kwaye nayiphi na enye yezi mpucuko inokutshintsha ubomi bakho bubengcono.
- Iphucula impilo yentliziyo
- Yongeza amandla
- Yandisa imetabolism
- Yehlisa ukudumba
- Isantya sokubuyisela kwingozi
- Yehlisa iintlungu
- Lola amehlo
- Ukuphucula ukuva
- Iyanciphisa ukuthanda izinto eziyingozi
- Ukunciphisa iimpawu zokurhoxa
- Inceda ukunciphisa umzimba
- Ikhusela imithambo-luvo
- Ithoba inkqubo yokuguga
Ngokucacileyo, izibonelelo zonyango lwe-NAD zime ekuphuculeni kakhulu impilo yakho yonke kunye nokuphila kakuhle, kunye nokuphucula iimpawu zezigulo ezimandundu.
Izifundobonisa ukuba unyango lwe-NAD lunokunciphisa iimpawu ze-Alzheimer's disease.Nangona oyena nobangela wesifo sika-Alzheimer useyimfihlakalo, siyazi ukuba kubandakanya ukufa kweeseli kunye nokungasebenzi kakuhle kwe-mitochondrial, zombini ezo zidilesi ze-NAD.Ngaphaya koko, iipropathi ze-NAD ze-neuroprotective zinokunceda ukukhusela lo monakalo kwindawo yokuqala.
Ixesha lokuposa: Sep-21-2023