Yintoni S-4 (Andrarine)

S-4, ithengiswe njengeandarine, i-oral bioavailable, i-non-steroidal ekhethiweyo ye-androgen receptor modulator (SARM).I-Andarine yi-agonist inxalenye ye-androgen receptor.

I-S-4 njengezinye ii-SARMS zaphuhliswa ekuqaleni kwe-2000s, ekuzameni ukunqoba imida ye-pharmacologic kunye ne-pharmacokinetic ye-steroidal androgen receptor agonists (oko kukuthi, i-testosterone kunye ne-DHT), eziye zaziwa imibutho kunye nesibindi kunye nesifo senhliziyo.

ICompound S-4 yayisetyenziswa kwizifundo zezilwanyana kodwa yayekwa phambi kwayo nayiphi na iSigaba soku-I solingo lweklinikhi lwabantu, ngenxa yomonakalo obonakalayo.Ezi ziphumo zenzeka njengoko i-molecule ye-S-4 ibophelela kwi-receptors kwiso;Okukhona kusiba ndlongondlongo kokubophelela, kokukhona ukungonwabi kusenzeka.Uphazamiso olubonakalayo lufunyaniswe luxhaphake kakhulu, ngenxa yentshukumo eyodwa yobuchwephesha, yechiza kangangokuba ulingo luyekwa.

Ingaba kwenzeka njaniS4Umsebenzi weAndarine

Enye yeendlela ezicetyiswayo zeS4, kukuba ivala ngokupheleleyo ukudityaniswa kwe-DHT.I-Dihydrotestosterone (i-DHT, i-5α-dihydrotestosterone, i-5α-DHT, i-androstanolone okanye i-stanolone) i-hormone yesini ye-androgen engapheliyo.Ngokumalunga ne-testosterone, i-DHT inamandla kakhulu njenge-agonist ye-androgen receptor.

I-S-4 ine-androgen receptor ephezulu (AR) yokubopha ubudlelwane.Uphononongo lubonise ukuba i-S-4 ayinamandla kwaye inamandla kune testosterone propionate (TP) kumsebenzi we-androgenic, kodwa umsebenzi wabo we-anabolic wawufana okanye umkhulu kune-TP.

I-S-4 i-androgen receptor agonist epheleleyo kwizicubu ze-muscle, kunye ne-agonist inxalenye kwi-prostate.Ngaloo ndlela, i-S-4 ikhuthaza ngamandla ukukhula kwemisipha, kodwa ayikwazi ukugcina ubungakanani beprotate.I-Testosterone ivuselela ukukhula kwemisipha kunye ne-prostate kumlinganiselo ofanayo.I-S-4 ibangela i-hormone ye-luteinizing ebalulekileyo (LH) okanye i-follicle evuselela ukunyanzeliswa kwehomoni.

S-4andarine) Iinzuzo

Nangona uphando oluninzi lwenziwe, uphando oluninzi luyaqhubeka kwaye kumanqanaba okuqala ophuhliso.Ukuphuhliswa kwe-SARMS yokusetyenziswa kweklinikhi kunye nonyango njengenye indlela ye-androgen, ithembisa ngokusekelwe kwidatha ye-preclinical.

Ngokungafani ne-anabolic steroids, ebophelela kwi-androgen receptors kwizicubu ezininzi kuwo wonke umzimba, i-SARM nganye ikhetha ukubopha i-androgen receptors kwizicubu ezithile, kodwa kungekhona kwabanye.Nangona kunjalo, basabonisa iziphumo ze-androgenic kunye ne-anabolic.

IiSARMS azikho i-anabolic steroids;kunokuba, ziyi-ligands zokwenziwa ezibophelela kwi-androgen receptors.Ngokuxhomekeke kwisakhiwo sabo se-molekyuli, benza njenge-agonists, i-agonists inxalenye kunye nabachasayo.Ngaloo ndlela ngendlela ekhethiweyo, ukuba i-SARMS imodareyitha okanye idibanise i-coregulators kunye nezinto ezibhaliweyo okanye izibonakaliso zeprotheyini ze-cascade ukukhuthaza umsebenzi we-anabolic.

Uphononongo lubonise i-S-4 i-androgen receptor agonist epheleleyo kwizicubu zemisipha, kunye ne-agonist inxalenye kwi-prostate, iyenza ibe ngumviwa ofanelekileyo njengenye indlela ye-steroidal androgen receptor agonists (okt, testosterone kunye ne-DHT), ngenxa yemiphumo emibi ehambelana nayo. kwisibindi, intliziyo, kunye nokuzala.

Kufuneka kuqatshelwe, ukuba nangona i-SARMS efana ne-S4 inyusa umsebenzi we-androgen, ayingomgqatswa osebenzayo wonyango lokutshintshwa kwehomoni, kuba ayifaki i-Estrogen.