Umgangatho oPhezulu weSteroids Raw Testosterone undecanoate ngexabiso eliPhezulu
I-Testosterone undecanoate yi-steroid ester.
I-Testosterone undecanoate yi-ester prodrug ye [testosterone] kwaye ine-acid-chain fatty acid kwi-carbon 17β isikhundla.Yaphuhliswa nge-fatty acid esterification ye testosterone ukuze kuphunyezwe i-testosterone yomlomo.Kukho iifomyula zomlomo kunye ne-intramuscular ezikhoyo kwi-testosterone undecanoate: zombini iifomyula ziboniswa kunyango lokubuyisela i-testosterone kumadoda amadala ane-hypogonadism.I-Testosterone yihomoni yendoda ebalulekileyo enoxanduva lokukhula okuqhelekileyo kunye nophuhliso lwamalungu esini sendoda kunye nokugcinwa kweempawu zesini sesibini.I-hypogonadism yamadoda, ebangelwa kukungonelanga kwe-testosterone secretion, inokubangela iimpawu kunye neempawu zokunqongophala kwe-testosterone, ezifana nokuncipha kwe-libido, ukungasebenzi kakuhle kwe-erectile, kunye nokulahlekelwa kwemisipha kunye namathambo.Unyango lokutshintshwa kwe-testosterone lujolise ekubuyiseleni amanqanaba e-testosterone, ngaloo ndlela kuphuculwe iimpawu kunye neempawu zokunqongophala kwe testosterone.
Testosterone Undecanoateyindlela ye-ester ye-undecanoate ye-androgen testosterone, kunye ne-gonadotropin-secretory inhibiting kunye nomsebenzi wokutshintshwa kwehomoni.Njengoko i-testosterone inqanda ukukhutshwa kwe-gonadotropins kwi-pituitary gland, ukulawulwa kwe-testosterone kunciphisa ukukhutshwa kwehomoni ye-luteinizing (LH).Ngokuthintela ukukhutshwa kwe-LH, ukukhula kweeseli ze-Leydig, ezihlala zikhuthazwa yi-LH ukuba zivelise i-testosterone, zinokucinezelwa.Ukongeza, le arhente ikhuthaza ukugcinwa kweempawu zesini zesini kwaye ingasetyenziselwa ukutshintshwa kwe testosterone kumadoda angama-hypogonadal.
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